Articles

Simple blood test could read state of Circadian Rhythm

  Determining the state of an individual’s internal physiological clock has important implications for precision medicine, from diagnosing neurological disorders to optimizing drug delivery. To be useful, such a test must be accurate, minimally burdensome to the...

Circadian Rhythms and Mood Disorders Genetically Linked

  A research team at the University of Glasgow has now identified a potential genetic link between disrupted circadian rhythms and mood disorders, including major depressive disorder (MDD) and neuroticism. The genome-wide association study (GWAS), involving data on...

Circadian Therapeutics are OBN Awards Finalists 2018

  We are pleased to announce that Circadian Therapeutics has been shortlisted into the final round of the 2018 OBN Awards.   This is the 10th anniversary of the OBN Awards, the UK life sciences industry’s most highly regarded awards event.  Circadian Therapeutics are...

How Does the Suprachiasmatic Nucleus (SCN) Control Circadian Rhythm?

The SCN is located in the anterior region of the hypothalamus, and contains roughly 20,000 neurons. The SCN can be divided into two main sections depending on the neuropeptide expression. The ‘Core’ of the SCN is mainly comprised of vasoactive intestinal peptide (VIP)...

Circadian Rhythm Disruption Linked to OCD

  Obsessive-compulsive disorder (OCD) is more common in people living in areas of high latitude, likely because of the effect of decreased sunlight on circadian rhythms, new research suggests. Investigators reviewed studies from more than 200 countries and identified...

Study Shows Circadian System Misalignment Impacts Insulin

The endogenous circadian system, behavioral cycle, and circadian misalignment have distinct effects on insulin sensitivity and β-cell function, according to a study published online June 4 in Diabetes, Obesity and Metabolism.   The researchers found that circadian...

Disrupted circadian rhythm increases risk of type 2 diabetes

A reversal of the day and night rhythm, due to shift work for example, leads to a disturbance in blood sugar levels. Scientists from Maastricht University have demonstrated this for the first time in humans. Their research shows that a disruption of the biological...

Research Shows Night Shifts Throw Brain Out of Sync

The Guardian reports that researchers have found working night shifts can impair the body’s natural rhythms so significantly that the brain and digestive system end up completely out of sync with each other. Scientists revealed that working three night shifts in a row...

New Study Links Circadian Rhythms and Alzheimer’s

A Finnish study published in the respected SLEEP journal shows that a variation in the melatonin receptor 1A (MTNR1A) gene is linked to the risk of Alzheimer's disease in the elderly. The same research team has previously demonstrated that the same genetic variation...

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